Ex vivo instability of glycated albumin: A role for autoxidative glycation
نویسندگان
چکیده
منابع مشابه
A review of glycated albumin as an intermediate glycation index for controlling diabetes.
INTRODUCTION This article reviews glycated albumin (GA) as a potential intermediate-term glycation index to fill the gap between self-monitoring of blood glucose (SMBG) and hemoglobin A1c testing in diabetes management. The introduction gives an assessment of available short-, medium-, and long-term glycemic indicators. METHODOLOGIES AND UTILITY: Methods of GA measurement are summarized, and th...
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Hyperglycemia-induced oxidative stress plays a key role in the onset/progression of cardiovascular diseases. For example, it can trigger formation of advanced glycation end (AGE) products with ischemia-reperfusion performed under hyperglycemic conditions. For this study, we hypothesized that albumin modified by glycation loses its unique cardioprotective properties in the setting of ischemia-re...
متن کاملMeasurement of protein glycation, glycated peptides, and glycation free adducts.
Protein glycation adducts, early glycation adducts, such as N(epsilon)-fructosyl-lysine, and advanced glycation end products (AGEs) are uremic toxins. Glycation adducts are found in plasma and tissue proteins (glycation adduct residues), in peptides (glycation adduct peptide residues), and glycated amino acids (glycation free adducts). The latter two analyte groups arise from proteolysis of gly...
متن کاملThe Roles of Glycated Albumin as Intermediate Glycation Index and Pathogenic Protein
The conventional glycemic indices used in management of diabetic patients includes A1c, fructosamine, 1,5-anhydroglucitol, and glycated albumin (GA). Among these indices, A1c is currently used as the gold standard. However, A1c cannot reflect the glycemic change over a relatively short period of time, and its accuracy is known to decrease when abnormalities in hemoglobin metabolism, such as ane...
متن کاملIntroduction of glycated albumin measurement for all blood donors and the prevalence of a high glycated albumin level in Japan
UNLABELLED (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00224.x, 2012) Aims/Introduction: The Japanese Red Cross Society introduced measurement of glycated albumin (GA) for all blood donors as a glycemic control marker. The GA levels were examined by sex and age. MATERIALS AND METHODS GA was measured in 3.14 million blood donors who donated between April 2009 and March 2010. For the r...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2017
ISSN: 0003-9861
DOI: 10.1016/j.abb.2017.07.004